There is anecdotal evidence, though no completed scientific studies, that Savannahs and other domestic hybrids (such as Bengals) do not respond well to anesthesia containing Ketamine. Many Savannah breeders request in their contracts that Ketamine not be used for surgeries.
Some (but not all) experienced Savannah breeders believe strongly that modified live vaccines should not be used on Savannahs, that only killed virus vaccines should be used. This, also, has not been studied.
Some breeders state that Savannah cats have no known special care or food requirements, while others recommend a very high quality diet with no grains or by-products. Some recommend a partial or complete raw feeding/raw food diet with at least 32% protein and no by-products. Servals often require calcium and other supplements (unless fed a natural, complete and raw diet), especially when growing, and some Savannah breeders recommend supplements as well, especially for the earlier generations. Others consider it unnecessary, or even harmful. Issues of Savannah diet are not without controversy, and again, it is best to seek the advice of a veterinarian or exotic cat specialist before feeding a Savannah cat any non-standard diet.
Many breeders also require you to have your Savannah declawed, both front and back feet. The method of choice for this proceedure is via Laser.